Selank – 10MG

Scientific Overview of Selank

Selank is a synthetic peptide derived from the natural tetrapeptide tuftsin, which is known for its involvement in immune regulation. Developed as a stabilized analog, Selank includes an additional tripeptide segment that may enhance its persistence and potential biological interactions in laboratory settings. Research interest in Selank extends to its possible roles in modulating neurotransmission, immune signaling pathways, and neuroplasticity.

Alternative Names: Synthetic Tuftsin Analog

Selank Studies and Research Data

Interactions with Neurotransmission Pathways

Experimental findings suggest that Selank may influence gamma-aminobutyric acid (GABA) receptor activity. Investigations have proposed that Selank might alter gene expression associated with neurotransmission and receptor affinity. This modulation appears to interact with benzodiazepine-related pathways, possibly indicating synergistic relationships. Other studies note potential stabilization of enkephalins, which may indirectly influence GABA receptor function and contribute to anxiolytic-like outcomes in animal models.

Selank Investigations into Immune Regulation

Selank has been observed in studies examining its potential to alter inflammatory signaling. Specifically, laboratory work has proposed that it may reduce interleukin-6 expression under stress-related conditions. Broader research points to its involvement with gene pathways linked to chemokines, cytokines, and immune balance. Experiments also suggest transient changes in spleen gene expression related to immune system modulation.

Selank Explorations in Lipid and Metabolic Research

Research in murine models has suggested that Selank exposure may correlate with shifts in lipid metabolism. Findings include reductions in circulating lipids such as cholesterol and triglycerides, along with possible changes in fibrinolytic activity and platelet aggregation. Additionally, studies have posited potential influences on glucose regulation and weight stability, though further work is needed to clarify these relationships.

Cognitive and Learning Studies

Laboratory experiments on learning and memory suggest that Selank may impact hippocampal gene expression linked to ion-regulated processes in neurons. Animal studies indicate potential improvements in memory retention and recall, along with possible enhancement of learning during repeated exposure. Some reports describe the peptide as supporting conditioned response consolidation and memory recovery after induced injury in research models.

Serotonin-Related Research

Experimental models indicate that Selank may influence serotonin metabolism, particularly when serotonergic synthesis is disrupted. Findings suggest a potential increase in serotonin turnover in brain regions associated with mood and anxiety regulation. These proposed interactions may highlight its relevance in studies of stress-related neurochemistry.

Neurotrophic Pathways

Selank has been studied for its possible impact on brain-derived neurotrophic factor (BDNF). Laboratory evidence suggests that it may increase hippocampal BDNF expression, especially under stress-related conditions where BDNF levels may otherwise be suppressed. This observation raises interest in Selank’s role in research on neuroplasticity.

Pain and Nociception Research

Investigations into Selank’s interaction with enkephalin-degrading enzymes propose that it may slow the breakdown of enkephalins. As enkephalins are associated with modulation of pain and stress responses, prolonging their activity might provide insights into nociceptive signaling. These findings remain preliminary, and further studies are needed to establish clear mechanisms.

Conclusion

Selank is a synthetic analog of tuftsin that has attracted research interest for its potential influences on neurotransmission, immune signaling, metabolic processes, cognitive functions, and neurotrophic factors. Laboratory studies suggest it may interact with multiple pathways, though findings remain exploratory and warrant further controlled investigation.

References

1. Inozemtseva, L. S., Karpenko, E. A., Dolotov, O. V., Levitskaya, N. G., Kamensky, A. A., Andreeva, L. A., & Grivennikov, I. A. (2008). Intranasal administration of the peptide Selank regulates BDNF expression in the rat hippocampus in vivo. Doklady Biological Sciences, 421, 241–243. https://doi.org/10.1134/s0012496608040066
2. Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front Pharmacol. 2016;7:31.
3. Agapova TIu, Agniullin IaV, Silachev DN, Shadrina MI, Slominskiĭ PA, Shram SI, Limborskaia SA, Miasoedov NF. [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex]. Mol Gen Mikrobiol Virusol. 2008;(3):28-32.
4. Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. [Experimental optimization of learning and memory processes by selank]. Eksp Klin Farmakol. 2010;73(8):2-5.
5. Kozlovskii II, Danchev ND. The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats. Neurosci Behav Physiol. 2003;33(7):639-43.
6. Uchakina ON, Uchakin PN, Miasoedov NF, Andreeva LA, Shcherbenko VE, Mezentseva MV, Gabaeva MV, Sokolov OIu, Zozulia AA, Ershov FI. [Immunomodulatory effects of selank in patients with anxiety-asthenic disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):71-5.
7. Kost, N. V., Sokolov, O. Iu., Gabaeva, M. V., Grivennikov, I. A., Andreeva, L. A., Miasoedov, N. F., & Zozulia, A. A. (2001). Semax and selank inhibit the enkephalin-degrading enzymes from human serum. Bioorganicheskaia Khimiia, 27(3), 180–183.
8. Zozulia AA, Neznamov GG, Siuniakov TS, Kost NV, Gabaeva MV, Sokolov OIu, Serebriakova EV, Siranchieva OA, Andriushenko AV, Telesheva ES, Siuniakov SA, Smulevich AB, Miasoedov NF, Seredenin SB. [Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(4):38-48.
9. Semenova TP, Kozlovskaya MM, Zakharova NM, Kozlovskii II, Zuikov AV. Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny. Bull Exp Biol Med. 2007;144(5):689-91.
10. N.F. Mjasoedov et al. The Influence of Selank on the Parameters of the Hemostasis System, Lipid Profile, and Blood Sugar Level in the Course of Experimental Metabolic Syndrome. 2014.
11. Semenova TP, Kozlovskiĭ II, Zakharova NM, Kozlovskaia MM. [Comparison of the effects of selank and tuftsin on the metabolism of serotonin in the brain of rats pretreated with PCPA]. Eksp Klin Farmakol. 2009;72(4):6-8.
12. Kasian A, Kolomin T, Andreeva L, Bondarenko E, Myasoedov N, Slominsky P, Shadrina M. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Rats. Behav Neurol. 2017;2017:5091027.
13. Sokolov OY, Meshavkin VK, Kost NV, Zozulya AA. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice. Bull Exp Biol Med. 2002;133(2):133-5.

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